Gastrointestinal Inherited Polyposis Syndromes
نویسندگان
چکیده
منابع مشابه
Colorectal polyposis and inherited colorectal cancer syndromes
The majority of colorectal cancer (CRC) cases are sporadic, with hereditary factors contributing to approximately 35% of CRC cases. Less than 5% of CRC is associated with a known genetic syndrome. Although adenomatous polyposis syndromes, hamartomatous polyposis syndromes, and those previously classified as non-polyposis CRC syndromes are quite rare, it is important for clinicians to know the c...
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There are multiple hereditary and non-hereditary polyposis syndromes that were originally categorized as adenomatous or hamartomatous. More recently, serrated polyps and their syndromes have been defined. Nearly all of these syndromes have a risk of colorectal cancer in the individuals and affected family members. Most of these syndromes are associated with extracolonic manifestations, includin...
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When Policy Topic is covered Genetic testing for APC gene mutations may be considered medically necessary in the following patients: At-risk relatives (see Considerations) of patients with FAP and/or a known APC mutation. Patients with a differential diagnosis of attenuated FAP vs. MYH-associated polyposis vs. Lynch syndrome. Whether testing begins with APC mutations or screening for MMR mu...
متن کاملScreening and surveillance recommendations for pediatric gastrointestinal polyposis syndromes.
Inherited polyposis syndromes are relatively rare disorders in pediatric gastroenterology practice, even in busy academic settings. It is important, however, for pediatric gastroenterologists to be aware of the serious health risks for children and their families affected by these disorders. The diagnosis of a polyp syndrome is often made in the first or second decade of life, long before the r...
متن کاملHamartomatous Polyposis Syndromes: Management and Surveillance Strategies
Introduction: Hamartomatous Polyposis Syndromes (HPS) are a rare group of dominant autosomal inheritance, which is characterized by the development of hamartomatous polyps in the gastrointestinal tract. This syndrome included Juvenile Polyposis syndrome (JPS), Peutz-Jeghers syndrome (PJS), and PTEN Hamartoma Tumour Syndrome (PHTS). PTEN Hamartoma Tumour Syndrome (PHTS) itself includes Cowden ...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2003
ISSN: 0893-3952,1530-0285
DOI: 10.1097/01.mp.0000062992.54036.e4